Observe Closely (one)pentobarbital will decrease the extent or effect of mifepristone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. CYP3A4 inducers have not been studied, coadministration not recommended by makerpentobarbital will decrease the level or impact of pitolisant by influencing hepatic/intestinal enzyme CYP3